U.S. FDA Approves Takeda’s ORZEYFUL™ (oveporexton), the First and Only Medicine to Treat the Underlying Cause of Narcolepsy Type 1

OSAKA, Japan & CAMBRIDGE, Mass. - Thursday, 06. August 2026


    Adults Taking ORZEYFUL Experienced Significant and Meaningful Improvements Across the Full Range of Symptoms of Narcolepsy Type 1 (NT1) in Clinical Trials Compared to Those on Placebo
    As a First-in-Class Orexin Treatment, ORZEYFUL has the Potential to Redefine NT1 Care Beyond Individual Symptoms
    Takeda is Advancing U.S. Launch Preparations and Expects to Make ORZEYFUL Available Following Completion of the Drug Enforcement Administration (DEA) Scheduling Process

 

(BUSINESS WIRE)--Takeda (TSE:4502/NYSE:TAK) announced that the U.S. Food and Drug Administration (FDA) approved ORZEYFUL™ (oveporexton), an oral orexin receptor 2 (OX2R) agonist, for the treatment of narcolepsy type 1 (NT1, narcolepsy with cataplexy) in adults.* The persistent 24-hour nature of NT1 is driven by orexin deficiency and can severely impact people’s lives. As a first-in-class orexin treatment, ORZEYFUL is the only medicine indicated in the U.S. to treat the disease holistically rather than individual symptoms.

“The FDA approval of ORZEYFUL marks a new chapter for the narcolepsy type 1 community, as we introduce an entirely new class of medicine that will potentially redefine how this disease is managed and how people feel on treatment,” said Julie Kim, president and chief executive officer of Takeda. “We are proud to have discovered and developed this orexin treatment innovation and will bring it to adults living with NT1 as quickly as possible.”

NT1 is a rare, chronic neurological disease driven by a loss of orexin and affects an estimated 120,000 people in the U.S. People with NT1 experience excessive daytime sleepiness, cataplexy (sudden loss of muscle tone), cognitive symptoms and disrupted nighttime sleep that can severely impact multiple aspects of daily life, including work, education and social interactions.

"For those of us living with narcolepsy type 1, symptoms reshape everyday life and extend far beyond what most people understand about the condition," said Julie Flygare, President and CEO at Project Sleep and a person with NT1. "ORZEYFUL’s approval is a historic moment that expands our treatment choices and gives me great hope for the future and for our community."

“Until now, people have managed narcolepsy type 1 with treatments that target symptom relief,” said Dr. Emmanuel Mignot, M.D., Ph.D., principal U.S. investigator in the ORZEYFUL Phase 3 program. “As the first and only approved orexin therapy to treat the broad spectrum of the disease, ORZEYFUL can enable a different kind of conversation in the doctor’s office about treatment options.”

The approval is based on a comprehensive clinical program including the global Phase 3 FirstLight (TAK-861-3001) and RadiantLight (TAK-861-3002) studies that showed oveporexton offers statistically significant improvements across the full range of symptoms of the disease. These included improvements in excessive daytime sleepiness, cataplexy and health-related quality of life. Oveporexton was generally well-tolerated with a safety profile consistent across clinical studies to date. The most common side effects include trouble sleeping (insomnia), urinary urgency, urinary frequency and excessive saliva. Learn more about the Phase 3 data results here.

"With this approval, we are turning scientific discovery into reality for adults living with narcolepsy type 1," said Andy Plump, M.D., Ph.D., President, Research & Development, Takeda. "ORZEYFUL is just the beginning. With orexin emerging as a powerful therapeutic pathway, Takeda is unlocking the potential of this new class of medicine for patients across a range of disorders.”

Next Steps for ORZEYFUL Availability

The controlled substance classification for ORZEYFUL is currently under review by the Drug Enforcement Administration (DEA) and is expected within 90 days. After the controlled substance classification is determined, ORZEYFUL will be made available through a specialty pharmacy to U.S. healthcare providers and adults living with NT1. To sign up for updates visit ORZEYFUL.com.

The FDA approval is not expected to have a significant impact on the full year consolidated financial forecast for the fiscal year ending March 31, 2027.

*For information regarding the submission of the new drug application for oveporexton to the U.S. FDA, please refer to Takeda’s press release dated February 10, 2026, “U.S. Food and Drug Administration Accepts New Drug Application and Grants Priority Review for Takeda’s Oveporexton (TAK-861) as a Potential First-in-Class Therapy for Narcolepsy Type 1”.

About ORZEYFUL (oveporexton)

ORZEYFUL (oveporexton) is an oral orexin receptor 2 (OX2R) agonist, which selectively stimulates the OX2R to restore signaling and address the underlying orexin deficiency associated with narcolepsy type 1 (NT1). By activating OX2Rs, ORZEYFUL promotes wakefulness and reduces abnormal rapid eye movement (REM)-sleep like phenomena, including cataplexy (sudden and temporary loss of muscle tone), to address a range of daytime and nighttime symptoms as evaluated in clinical studies and consistent with the approved label.

INDICATION

ORZEYFUL is indicated for the treatment of narcolepsy type 1 (narcolepsy with cataplexy) in adult patients.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

ORZEYFUL is contraindicated in patients taking strong CYP3A inhibitors.

WARNINGS AND PRECAUTIONS

Insomnia: In pooled phase 3 studies in patients with NT1, 60%, 55%, and 1% of patients in the ORZEYFUL 2 mg twice daily, ORZEYFUL 1 mg twice daily, and placebo groups, respectively, developed insomnia. Prior to ORZEYFUL treatment initiation, inform patients about the risk of insomnia at initiation of treatment. If insomnia persists beyond 7 days and significantly impacts daytime functioning or quality of life, consider ORZEYFUL dosage reduction or discontinuation.

Urinary Frequency and Urgency: ORZEYFUL may cause or worsen urinary frequency and urgency. In pooled phase 3 studies in patients with NT1:

    58%, 53%, and 5% of patients in the ORZEYFUL 2 mg twice daily, ORZEYFUL 1 mg twice daily, and placebo groups, respectively, developed urinary frequency.
    16%, 15%, and 1% of patients in the ORZEYFUL 2 mg twice daily, ORZEYFUL 1 mg twice daily, and placebo groups, respectively, developed urinary urgency.

These lower urinary tract symptoms are consistent with ORZEYFUL’s mechanism of action through agonism of the orexin receptor 2 (OX2R) on central micturition pathways. Prior to initiation of ORZEYFUL treatment, inform patients about the risk of urinary frequency and urgency and screen for lower urinary tract symptoms. Monitor ORZEYFUL-treated patients with a history of overactive bladder for worsening urinary tract symptoms.

Creatine Phosphokinase Elevations: In pooled phase 3 studies in patients with NT1, asymptomatic creatine phosphokinase elevations >5x ULN were observed in 11% (21/196) of ORZEYFUL-treated patients and 5% (4/76) of placebo treated patients. Two of these cases were characterized by markedly elevated CPK and transaminase levels; both patients discontinued treatment. None of the cases were associated with myoglobinuria or renal impairment. Advise patients to report unexplained muscle pain, weakness, or dark urine, particularly when engaging in vigorous physical activity or taking concomitant drugs associated with myotoxicity.

ADVERSE REACTIONS

The most common adverse reactions (incidence ≥5% and greater than placebo) reported in phase 3 studies with ORZEYFUL were insomnia, pollakiuria, micturition urgency, and salivary hypersecretion.

DRUG INTERACTIONS

    Concomitant use with strong or moderate CYP3A inhibitors increases oveporexton exposures, which may increase the risk of ORZEYFUL-associated adverse reactions
    Concomitant use of strong and moderate CYP3A inducers can increase oveporexton metabolism and decrease plasma levels of oveporexton, which may decrease the effectiveness of ORZEYFUL

USE IN SPECIFIC POPULATIONS

Pregnancy: There is a pregnancy exposure registry that monitors pregnancy outcomes in women who are exposed to ORZEYFUL during pregnancy. Patients should be encouraged to enroll in the ORZEYFUL pregnancy registry if they become pregnant. To enroll or obtain information from the registry, patients can call 1-877-371-0309. Available data from clinical trials with ORZEYFUL use during pregnancy are insufficient to identify a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes.

Lactation: There are no data available on the presence of oveporexton in human milk, the effects on the breastfed infant, or the effects on milk production. Animal studies indicate that oveporexton was present in the milk of lactating rats. When a drug is present in animal milk, it is likely that the drug will be present in human milk.

Hepatic Impairment: Avoid use of ORZEYFUL in patients with severe hepatic impairment (Child-Pugh C), as it has not been studied in this population.

Renal Impairment: Avoid use of ORZEYFUL in patients with severe renal impairment on dialysis (eGFR <15 mL/minute), as it has not been studied in this population.

DRUG ABUSE AND DEPENDENCE

ORZEYFUL contains oveporexton. Controlled substance schedule to be determined after review by the Drug Enforcement Administration.

ORZEYFUL has potential for abuse and misuse. Carefully evaluate patients for a recent history of drug abuse, especially those with a history of CNS stimulant, and follow such patients closely, observing them for signs of misuse or abuse of ORZEYFUL.

Important Note: Prescribing Information is subject to change pending DEA scheduling and final label publication.

Please click for Full Prescribing Information.

About Takeda’s Orexin Franchise

Takeda is the leader in orexin science with a tailored portfolio of investigational orexin agonists in pre-clinical and clinical stages for multiple-sleep wake disorders and other indications where orexin plays a role including respiration, mood and metabolism. ORZEYFUL (oveporexton) is the lead orexin receptor 2 (OX2R) agonist asset in Takeda’s orexin franchise and has been approved by regulatory bodies in China and the United States for the treatment of narcolepsy type 1 (NT1). The company is also investigating other oral orexin agonists, including TAK-360 being investigated for the treatment of NT1, narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH), as well as TAK-495.

About Takeda

Takeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R&D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit www.takeda.com.

Important Notice
For the purposes of this notice, “press release” means this document, any oral presentation, any question-and-answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.

The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.

Forward-Looking Statements
This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects”, “forecasts”, “outlook” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States and with respect to international trade relations; competitive pressures and developments; changes to applicable laws and regulations, including tax, tariff and other trade-related rules; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic; the success of our environmental sustainability efforts, in enabling us to reduce our greenhouse gas emissions or meet our other environmental goals; the extent to which our efforts to increase efficiency, productivity or cost-savings, such as the integration of digital technologies, including artificial intelligence, in our business or other initiatives to restructure our operations will lead to the expected benefits; and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: https://www.takeda.com/investors/sec-filings-and-security-reports/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.

Medical Information

This press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.

 

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Contacts

Investor Relations
Christopher O’Reilly
takeda.ir.contact@takeda.com

Media Relations
Cassie Ercanbrack (Boston)
Media_relations@takeda.com

Tsuyoshi Tada (Tokyo)
Toiawase_kouhou@takeda.co.jp

Mary Kay’s Pink Changing Lives® Program Turns Purpose Into Measurable Impact for Women Around the World

 More than 4 million women have benefited through nonprofit organizations supported by the program since its launch.

 

(BUSINESS WIRE)--Mary Kay Inc., a global advocate for women’s empowerment, proudly reaffirms its commitment to enriching women’s lives worldwide through its signature Pink Changing Lives® Program – a multi-faceted global initiative that blends purpose-driven giving with cause-marketing to create meaningful, measurable impact across communities. Since 1996, the program has provided over $230 million in monetary and product donations to nonprofit organizations empowering women, transforming women’s health and safety, and protecting our natural resources.

Rooted in the Company’s mission of enriching women’s lives, the Pink Changing Lives® cause-marketing campaign transforms everyday beauty purchases into powerful acts of giving. With over $19 million funneled back into local communities, funded through a portion of sales from designated products across participating markets, the program enables Mary Kay to partner locally and act globally – supporting causes that matter most to women and their families. Each purchase of a Pink Changing Lives®-designated product directly contributes to charitable efforts, allowing consumers to participate in giving back through their everyday choices.

“At Mary Kay, we believe in the power of small acts to create extraordinary change,” said Allison Levy, Chief Legal Officer and Corporate Secretary at Mary Kay Inc. “Through Pink Changing Lives®, every market, consumer, Independent Beauty Consultant and designated purchase has the power to uplift a woman, support a family, and strengthen a community. This program reflects who we are at our core – a company committed to turning purpose into action and creating a world where every woman can thrive.”

Since its inception, the program has evolved into a cornerstone of Mary Kay’s global social impact strategy, supporting initiatives that advance cancer research, aid survivors of domestic violence, expand access to education, protect the environment, and help communities thrive around the world.

A Global Movement, Powered Locally

Pink Changing Lives® drives impact through the passion of Mary Kay’s independent sales force and employees, who activate the program in markets around the world, bringing its mission to life through locally relevant partnerships and initiatives. Across regions, markets are turning shared purpose into tangible outcomes:

Mary Kay China: Through the Hope for Pearl Program, Beauty Consultants help fund educational opportunities for girls from disadvantaged backgrounds, linking beauty experiences to life-changing educational access.

Mary Kay Germany global outreach efforts: Partnerships with organizations like the Reiner Meutsch FLY & HELP Foundation have expanded access to education through the construction and renovation of 12 schools in underserved regions, including Africa and South Asia.

Mary Kay Colombia: In partnership with Fundación Colombianitos, funding supports the creation of safe spaces for children to learn, grow, and play. Projects have included the restoration of a neglected sports field and multipurpose room to allow for after-school activities and community building through sport, play, recreation, education, and health.

Other global markets: Thousands of nonprofit partnerships support critical causes from domestic violence prevention and cancer care to community beautification projects - all tailored to the needs of local communities.

By empowering each Mary Kay market to select causes and partners aligned with local priorities, Pink Changing Lives® ensures that impact is not only global in scale but deeply personal in execution.

Cause Marketing That Creates Lasting Impact

Pink Changing Lives® is a powerful cause-marketing model – where purpose and product intersect. This model not only raises critical funds but also builds awareness and engagement, creating a ripple effect of purpose that extends far beyond the point of sale. The result is a sustainable approach to philanthropy – one that empowers individuals, drives community involvement, and reinforces Mary Kay’s longstanding commitment to social good.

Did You Know:

Mary Kay ranked #8 out of 5,500 brands on Forbes’s 2026 Best Brands for Social Impact1 moving up from stellar #9 achieved in 2025. Mary Kay is the only beauty brand in the Top 15 and the only direct selling company on the list.

Mary Kay has a presence in 40 markets around the world.

About Mary Kay

One of the original glass ceiling breakers, Mary Kay Ash founded her dream beauty brand in Texas in 1963 with one goal: to enrich women’s lives. That dream has blossomed into a global company with millions of independent sales force members in 40 markets. For over 60 years, the Mary Kay opportunity has empowered women to define their own futures through education, mentorship, advocacy, and innovation. Mary Kay is dedicated to investing in the science behind beauty and manufacturing cutting-edge skincare, color cosmetics, nutritional supplements, and fragrances. Mary Kay believes in preserving our planet for future generations, protecting women impacted by cancer and domestic abuse, and encouraging youth to follow their dreams. Learn more at marykayglobal.com. Find us on Facebook, Instagram, and LinkedIn.

____________________________ 

1 Alan Schwarz (March 17, 2026). Forbes - Best Brands For Social Impact 2026. https://www.forbes.com/lists/best-brands-social-impact/

 

 

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Mary Kay Inc. Corporate Communications

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972.687.5332 or media@mkcorp.com

 

Perpetuals Reports 380% Hypothetical Return in Backtest of AI Engine Powering Risk-Free Trading Platform ‘UpsideOnly’

 

• Results provide early evidence that BayesShield can identify potentially profitable trading signals by finding repeatable skill in trader activity
• 375-day backtest using Perpetuals’s production code generated a hypothetical 380% non-compounded return, a period in which Bitcoin fell 40.2%
• The strategy achieved a return-to-drawdown ratio of 4.4, a measure comparing its overall return with the largest decline it experienced during the test

 

(BUSINESS WIRE)--Perpetuals.com Ltd (Nasdaq: PDC) today announced backtest results for version two of BayesShield, its patent-pending AI engine developed for UpsideOnly.

UpsideOnly is a risk-free paper trading platform where users simulate trades using virtual money across global equity, commodity, foreign exchange and crypto markets. The platform is powered by BayesShield, an AI model that uses machine learning to identify consistently successful traders. It generates automated signals when enough qualified traders independently take the same position at approximately the same time. These signals inform UpsideOnly's trading strategies, with profits shared among eligible top-performing users.

Using the same production code that powers the live platform, Perpetuals replayed approximately 1.07 billion historical order fills. Over the 375-day test period, the strategy generated a hypothetical, non-compounded return of 380%, with a maximum drawdown, meaning its largest decline from a previous peak, of 27%. It achieved a return-to-drawdown ratio of 4.4, indicating that its overall gains were substantially greater than its largest setback during the test.

Starting with $400,000 in simulated deployed capital, the system generated $1.522 million in hypothetical profit, ending the test with $1.922 million. If replicated in live markets, the results point to a different role for AI in trading: identifying repeatable human skill across large volumes of market activity and turning it into automated trading signals, rather than trying to predict prices directly.

Encouragingly, the strategy remained resilient under market stress. It recorded a positive return in every calendar quarter and zero liquidations across the 375-days, a period when Bitcoin fell 40.2%. During the sharp market sell-off on October 10, 2025, the system was essentially flat, declining by just 0.7%, while Bitcoin fell 16% within hours.

"This massive backtesting effort has provided promising signals that our BayesShield AI algorithm is working as intended,” said Patrick Gruhn, CEO of Perpetuals. "Our early live, real-money results have been encouraging and generally consistent with this testing”

This testing protocol was designed to reduce bias and prevent the use of future information, drawing on data from more than 429,000 trading accounts, 70.8 million positions sourced from PM MTF Ltd and more than 22 billion historical retail trades.

UpsideOnly launched in May 2026 and now has more than 225,000 users and recorded $70 billion in simulated notional trading volume across 25 assets. The live trading period remains too limited to draw conclusions about future performance.

About Perpetuals.com Ltd

Perpetuals.com Ltd (Nasdaq: PDC) is a fintech company developing AI-powered trading products and prediction markets, with a global footprint across the United States, Europe, and Asia. Its mission is to reduce risk through empowering retail users with intuitive, secure, and efficient trading experiences that span the world’s capital markets. UpsideOnly, the company's flagship consumer product, is the first risk-free trading platform, pairing human market insight with proprietary BayesShield AI so users can share in trading profits without ever risking their own money.

Perpetuals’s proprietary AI system, BayesShield AI, combines advanced AI and data analysis. The technology is trained on billions of trades, monitors market activity in real time, identifies patterns for trading and risk decisions, and provides multi-asset coverage. The company’s technology is used by the EU-licensed Perpetual Markets Multilateral Trading Facility (MTF), PM MTF Ltd, which operates under full MiFID II, MiCA, DORA, and EMIR compliance.

Forward-Looking Statements: This press release contains forward-looking statements as defined within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the anticipated profitability to the company and users of UpsideOnly. Words such as “expect,” “will,” “positions,” “advancing,” “projected,” “anticipated,” and other similar expressions indicate forward-looking statements, though not all forward-looking statements contain such words. These statements reflect the company’s current view with respect to future events and are subject to risks and uncertainties that could cause actual results to differ materially. The performance results described in this release are derived from a back-test conducted using historical data under specified assumptions and methodologies. Back-tested results are achieved through the application of hindsight and do not represent the results of actual trading or live operation. Such results are subject to inherent limitations, including assumptions regarding historical data, model design, and analytical methodology, and may not reflect the impact of market conditions, execution factors, transaction costs, liquidity constraints, or other variables that could affect actual performance. Past or simulated performance is not indicative of future results, and there can be no assurance that similar results will be achieved in actual operation. Future results are subject to, among other things, the efficacy and accuracy of BayesShield AI, regulatory scrutiny, continued user participation in the UpsideOnly platform, market conditions, the issuance and enforceability of the patent covering BayesShield AI, the company’s ability to raise capital to support the operation of the UpsideOnly platform, and risks detailed in the company’s filings with the Securities and Exchange Commission. Forward-looking statements are necessarily based upon a number of estimates and assumptions that, while considered reasonable by the company, are inherently subject to significant business, economic, competitive, political, regulatory, and social uncertainties and contingencies. Should one or more of these risks or uncertainties materialize, or should the assumptions set out by the company underlying those forward-looking statements prove incorrect, actual results may vary materially from those described herein. Individuals are cautioned that forward-looking statements are not guarantees of future performance and accordingly investors are cautioned not to put undue reliance on forward-looking statements due to the inherent uncertainty therein. These forward-looking statements are made as of the date of this press release and the company does not undertake any obligation to update these forward-looking statements, except as required by law. Perpetuals.com Ltd has an option agreement to acquire the affiliate company PM MTF Ltd, which will require a change of control approval by CySEC if exercised. Risk-free trading means that no losses from trading losses can occur to users, but does not include risks from other sources, including, but not limited to, the operational risks of the company.

We may use blog posts on our website as well as our social media accounts, including our accounts on X, LinkedIn, and Facebook, to disclose material information about the company from time to time.

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Media Contact: press@perpetuals.com

Investor Relations: ir@perpetuals.com

Laserfiche Launches Advanced Enterprise Security to Deliver Multi-Region Disaster Recovery and GovRAMP-Ready Compliance for Highly Regulated Industries

 

New security suite extends Laserfiche’s proven security controls and adds near real-time data replication for governments, law enforcement and security-conscious enterprises.

(BUSINESS WIRE) -- Laserfiche — the leading SaaS provider of intelligent content management — today announced the launch of Enterprise Security, an advanced suite of security enhancements designed for organizations navigating complex regulatory environments. Enterprise Security addresses GovRAMP and CJIS (Criminal Justice Information Services) security requirements based on the NIST SP 800-53 framework. For organizations handling privileged citizen, legal or corporate data, these built-in controls streamline audit preparation and fortify defenses.

With organizations placing a higher priority on data stewardship and corporate governance, enterprise IT leaders require a security architecture that protects data without slowing down operations. Laserfiche Enterprise Security extends Laserfiche Cloud’s highly resilient infrastructure with multi-region data replication, elevated security controls for privileged accounts, and built-in governance safeguards.

“Maintaining data integrity and compliance has always been at the heart of Laserfiche’s operations,” said Michael Allen, CTO at Laserfiche. “With Enterprise Security, Laserfiche provides enterprise IT users, especially those in government, law enforcement and highly regulated industries, with the complementary controls designed to meet stringent information security standards and protect their most sensitive assets.”

High-Security Controls and Regulatory Alignment

Laserfiche Enterprise Security introduces multi-region disaster recovery, enhanced oversight capabilities, and government-ready cloud security controls tailored for mission-critical data and sensitive operations.

Key capabilities included with Enterprise Security:

GovRAMP and CJIS Readiness: Deploys advanced operational controls designed to meet strict government and criminal justice compliance mandates for sensitive data handling.

Multi-region disaster recovery: Safeguards critical operations against large-scale infrastructure failures with near real-time, account-level repository data replication and multi-region failover.

Advanced audit tracking and analytics: Provides complete visibility into user login activity, system changes, and security events

Proactive threat augmentation: Bolsters existing security measures by adding specialized protections against unauthorized AI bot scraping and distributed denial of service (DDoS) attacks.

Laserfiche is listed on the GovRAMP Progressing Product List, with the Enterprise Security suite delivering the architectural controls required to support these standards.

Tailored for Mission-Critical Operations

Enterprise Security is built for organizations that safeguard heavily regulated and sensitive data, where seamless recovery and strict information control are vital to everyday operations:

Government agencies and law enforcement: Safely manage records and criminal justice information while strictly adhering to CJIS and GovRAMP standards.

Large enterprises and financial services: Protect proprietary corporate data and client financials with strong cryptographic modules and advanced visibility into user activity.

“Highly regulated sectors, from law enforcement to state and local governments, face a unique challenge: They must modernize content management while upholding non-negotiable security standards,” said Andrea Malick, principal advisory director at Info-Tech Research Group. “Solutions that offer built-in compliance frameworks like CJIS and GovRAMP give enterprise IT buyers the confidence to migrate sensitive workloads to the cloud without compromising control.”

Pricing and Availability

Enterprise Security is available starting today as a supplemental SKU for qualifying Laserfiche Cloud deployments.

Laserfiche is also introducing Business+, a new comprehensive subscription tier designed for organizations that want high-level security capabilities built directly into their standard platform deployment.

For More Information

For a deep-dive into Laserfiche security and governance, visit laserfiche.com/products/trust-security.

About Laserfiche

Laserfiche is the leading enterprise platform that helps organizations digitally transform operations and manage their content with AI-powered solutions. Through scalable workflows, customizable forms, no-code templates and AI-enabled capabilities, the Laserfiche® document management platform accelerates how business gets done. Trusted by organizations of all sizes — from startups to Fortune 500 enterprises — Laserfiche empowers teams to boost productivity, foster collaboration, and deliver a superior customer experience at scale. Headquartered in Long Beach, California, Laserfiche operates globally, with offices across North America, Europe and Asia.

Connect with Laserfiche:

Laserfiche Blog | X | LinkedIn | Facebook | YouTube

 

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Media Contact:

Linda Domingo

Communications Director, Laserfiche

Linda.domingo@laserfiche.com

562-988-1688 ext. 234

Bitget Signs Cooperation Agreement with Gelephu Mindfulness City Authority to Explore Licensed Digital Asset Presence in Bhutan

VICTORIA, Seychelles and GELEPHU, Bhutan - Thursday, 06. August 2026

(GLOBE NEWSWIRE) -- Bitget, the world’s leading Universal Exchange, has signed a cooperation agreement with the Gelephu Mindfulness City Authority, marking a step toward establishing a local presence in Gelephu Mindfulness City, Bhutan.

The agreement sets out a framework for Bitget to establish a legal presence in GMC, prepare an application for the relevant Financial Services Licence under the regulatory framework administered by the Gelephu Financial Services Office, and work with GMCA on operational, regulatory and ecosystem-building workstreams. The cooperation is intended to support the growth of the digital asset ecosystem in GMC, subject to the required approvals.

“Bhutan is approaching digital assets with a rare mix of long-term thinking, clean-energy advantage and regulatory clarity,” said Gracy Chen, CEO at Bitget. “GMC is the emerging hotbed for digital finance, and Bitget looks forward to contributing exchange experience, infrastructure knowledge and local talent development as this ecosystem grows.”

Bhutan has become one of the most closely watched sovereign stories in digital assets. The country has used its hydropower resources to support green cryptocurrency mining as part of a broader strategy to stimulate economic growth, create new employment pathways and retain young talent.

GMC adds a new dimension to this story. As a Special Administrative Region in southern Bhutan, GMC is being developed as a next-generation international financial and innovation hub. Its financial services and virtual asset regime is governed by the Financial Services Act 2025 and subsidiary rulebooks, with firms carrying on regulated financial services or virtual asset activities in or from GMC required to obtain a Financial Services Licence from the GFSO.

“Our objective is to build a world-class digital asset ecosystem founded on robust regulation, institutional standards and long-term economic value. Partners such as Bitget play an important role in bringing global expertise while contributing to the development of local capabilities and the broader financial ecosystem,” said Jigdrel Singay, Board Director of Gelephu Mindfulness City.

Bhutan’s broader openness to responsible digital innovation has already drawn international attention. In Dec 2025, through the Bitcoin Development Pledge, Bhutan has signalled its long-term commitment to responsibly integrating digital assets into its economic development strategy, while fostering an ecosystem built on sound regulation, institutional participation and long-term value creation.

Through this cooperation, Bitget intends to contribute global exchange experience, market infrastructure knowledge and digital asset industry expertise to GMC’s emerging ecosystem. The planned local setup includes local hiring and office presence over time, helping support GMC’s wider focus on substance, talent development, knowledge transfer and long-term capability building.

About Bitget

Bitget is the world's largest Universal Exchange (UEX), serving over 125 million users and offering access to over 2M crypto tokens, 500+ tokenized stocks, ETFs, commodities, FX, and precious metals such as gold. The ecosystem is committed to helping users trade smarter with its AI agent, which co-pilots trade execution. Bitget is driving crypto adoption through strategic partnerships such as MotoGP™. Aligned with its global impact strategy, Bitget has joined hands with UNICEF to support blockchain education for 1.1 million people by 2027. Bitget currently leads in the tokenized TradFi market, providing the industry's lowest fees and highest liquidity across 150 regions worldwide.

For more information, visit: Website | X | Telegram | LinkedIn | Discord

For media inquiries, please contact: media@bitget.com

Risk Warning: Digital asset prices are subject to fluctuation and may experience significant volatility. Investors are advised to only allocate funds they can afford to lose. The value of any investment may be impacted, and there is a possibility that financial objectives may not be met, nor the principal investment recovered. Independent financial advice should always be sought, and personal financial experience and standing carefully considered. Past performance is not a reliable indicator of future results. Bitget accepts no liability for any potential losses incurred. Nothing contained herein should be construed as financial advice. For further information, please refer to our Terms of Use.

About Gelephu Mindfulness City

The Gelephu Mindfulness City Special Administrative Region is a visionary initiative creating a world-class economic hub in southern Bhutan, centered on mindfulness, sustainability, and innovation. The SAR integrates traditional Bhutanese values with globally recognized legal frameworks, cutting-edge design and technology, while harnessing the Kingdom’s abundant renewable energy resources to serve as a global exemplar of holistic development.

For more information, visit www.gmc.bt or contact info@gmc.bt

Investment inquiries: invest@gmc.bt

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/9844bc4e-17d8-4724-af40-c4fa909e340a

Khimji Ramdas Group Chooses Rimini Street to Reduce SAP Support Costs, Protect 700+ Customizations and Reinvest Savings in Innovation

 LAS VEGAS - Thursday, 06. August 2026 AETOSWire 

Omani conglomerate gains greater control over its IT roadmap, avoids migration pressure and funds AI and growth initiatives

(BUSINESS WIRE) -- Rimini Street, Inc. (Nasdaq: RMNI), the Software Support and Agentic AI ERP Company™ and the leading third-party support provider for Oracle, SAP and VMware software, today announced that Khimji Ramdas Group, one of Oman’s largest privately held conglomerates, has selected Rimini Support™ for SAP, a move that has helped the organization reduce costs, reinvest savings in AI innovation and maintain its highly customized SAP ECC 6 environment with zero downtime.

“Staying on SAP ECC is a strategic decision for us,” said Prashant Kumar, CTO, Khimji Ramdas Group. “We went to an industry analyst to ask what options we have to keep our ECC systems running without vendor support dependencies, and they suggested that we contact Rimini Street for third-party support. Since moving, we see that we should’ve made this move years ago.”

Preserving flexibility and avoiding unnecessary migration

With more than 150 years of history and diversified interests across consumer products, retail, infrastructure and logistics, Khimji Ramdas Group relies on SAP to support critical business operations across its portfolio. Facing pressure to migrate to SAP S/4HANA, the company sought a more cost-effective path that would preserve its extensive customizations and allow leadership to determine its IT roadmap on business priorities rather than vendor timelines.

“Rimini Street significantly reduced our total SAP support costs by 80%, freeing up funds that we’re now investing in AI-driven innovation without undergoing migrations or replatforming,” said Kumar. “We have the same budget that we had when we were working with SAP, but now I can do more with it.”

Supporting a highly customized SAP environment

Khimji Ramdas Group’s SAP environment supports finance, supply chain, sales and other critical operations across a broad and complex business landscape. The environment includes more than 700 custom codes developed over many years to meet the company’s specific business requirements. According to Kumar, other providers were unwilling to support that level of customization, while Rimini Street demonstrated the expertise and commitment needed.

“In the last four years with Rimini Street, we haven’t had one instance of SAP going down,” Kumar noted. “When I talk to my people, they say the level of support and professionalism from the Rimini Street engineering team is unmatched, and that it puts them at ease.”

Rimini Street expertise helps Khimji Ramdas solve a regulatory compliance challenge

In addition to lowering costs and protecting custom code, Rimini Street helped Khimji Ramdas Group address a complex HR and payroll compliance challenge tied to Omani labor regulations. Working together, the teams developed a solution that enabled the company to move employees across business units while maintaining payroll alignment, helping avoid potential costly fines.

“There are stringent labor regulations, and the penalties for non-compliance can be very high, depending on the nature and extent of the violation. With Rimini Street's expertise in regulatory compliance, we were able to design a solution that strengthened our compliance framework and helped ensure we remain fully compliant with applicable regulations,” said Kumar.

Rimini Support™ gives organizations the freedom to choose what’s next

No longer feeling the pressure to migrate to S/4HANA or give up customizations and valuable perpetual licenses, Khimji Ramdas is focusing its people, time and budget to launch valuable projects, including a new Salesforce CRM program, expanded e-commerce capabilities and development of an in-house large language model connected to its data analytics platform.

"In today's highly competitive market, IT leaders can no longer afford to choose between growth and profitability. They must achieve both," said Nancy Lyskawa, EVP and chief client officer, Rimini Street. "We are proud to help clients like Khimji Ramdas Group realize immediate savings that support initiatives accelerating growth, increasing agility and achieving faster time to market, all on their own schedule and terms."

“We plan to stay on ECC until further notice because we have such outstanding support and the freedom to prioritize our business needs over vendor demands. We don’t need to choose between stability and innovation,” Kumar said. “Rimini Street is our go-to for expert support, guidance and whatever comes next.”

Learn how Khimji Ramdas Group is fueling growth with Rimini Street.

About Rimini Street, Inc.

Rimini Street, Inc. (Nasdaq: RMNI), a Russell 2000® Company, is a proven, trusted global provider of end-to-end, mission-critical enterprise software support, managed services and innovative Agentic AI ERP solutions, and is the leading third-party support provider for Oracle, SAP and VMware software. The Company has signed thousands of IT service contracts with Fortune Global 100, Fortune 500, midmarket, public sector and government organizations who have leveraged the Rimini Smart Path™ methodology to achieve better operational outcomes, billions of US dollars in savings and fund AI and other innovation.

To learn more, please visit www.riministreet.com, and connect with Rimini Street on X, Facebook, Instagram, and LinkedIn.

Forward-Looking Statements

Certain statements included in this communication are not historical facts but are forward-looking statements for purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Forward-looking statements generally are accompanied by words such as “anticipate,” “assume,” “believe,” “budget,” “continue,” “could,” “currently,” “estimate,” “expect,” “forecast,” “future,” “intend,” “may,” “might,” “outlook,” “plan,” “possible,” “goal,” “potential,” “predict,” “project,” “reflect,” “results,” “seem,” “seek,” “should,” “will,” “would” and other similar words, phrases or expressions. These forward-looking statements include, but are not limited to, statements regarding our expectations of future events, future opportunities, global expansion and other growth initiatives and our investments in such initiatives. These statements are based on various assumptions and on the current expectations of management and are not predictions of actual performance, nor are these statements of historical facts. These statements are subject to a number of risks and uncertainties regarding Rimini Street’s business, and actual results may differ materially. These risks and uncertainties include, but are not limited to our ability to attract new clients or retain and/or sell additional products or services to existing clients; our ability to achieve and maintain an adequate rate of revenue growth; cost of revenue, including changes in costs associated with our efforts to grow and the results of any efforts to manage costs to align with current revenue expectations and the expansion of our offerings; the effects of increased intense competition in our industry and our ability to compete effectively; our ability to successfully educate the market regarding the advantages of our support and managed services for ERP software and to sell the products and services comprising our “Rimini Smart Path™” solutions portfolio, including but not limited to our Agentic AI ERP solutions; our intentions with respect to our pricing model and expectations of client savings relative to use of other providers; the evolution of the ERP software management and support landscape facing our clients and prospects; estimates of our total addressable market; the effects of seasonal trends on our results of operations, including the contract renewal cycles for vendor-supplied software support and managed services; the effects of the efforts of enterprise software vendors to sell upgrades or migrations to cloud-based versions of their enterprise software on our results of operations; our ability to scale our operations quickly enough to meet our clients’ changing needs or decrease our costs adequately in response to changing client demand; risks arising from incorporating artificial intelligence (“AI”) technologies into our products or services or any deficiencies associated with AI technologies used by us or by our third-party vendors and service providers; our ability to maintain, protect, and enhance our brand; the loss of one or more members of our management team and our ability to attract and retain additional qualified technical, sales and marketing personnel; our ability to expand our marketing and sales capabilities; our ability to avoid interruptions to, or degraded performance of, our services and the impact of any such interruptions or performance problems on our operations; our ability to defend against cybersecurity threats and to comply with data protection and privacy regulations; our expectations regarding new product offerings, innovation solutions, partnerships and alliance programs and our ability to develop and maintain strategic partnerships; our ability to expand internationally and the risks associated with global operations; our wind down of support services for Oracle’s PeopleSoft software products and the impact on future period revenue and costs incurred related to these efforts; the continuing impact of and our ability to comply with the terms of our July 2025 settlement agreement with Oracle; the impact of macro-economic trends, including inflation and changes in foreign exchange rates, as well as general financial, economic, regulatory and political conditions affecting the industry in which we operate and the industries in which our clients operate; our ability to generate significant capital through our operations or to raise additional capital necessary to fund and expand our operations and invest in new services and products; our business plan and our ability to effectively secure and manage our growth and associated investments; risks relating to retention rates, including our ability to accurately predict retention rates; our ability to protect our intellectual property; our ability to maintain an effective system of internal control over financial reporting; changes in laws or regulations, including tax laws or unfavorable outcomes of tax positions we take; tariff costs; our ability to realize benefits from our net operating losses; any negative impact of environmental, social and governance (“ESG”) matters on our reputation or business and the exposure of our business to additional costs or risks from our reporting on such matters; our credit facility’s ongoing debt service obligations and financial and operational covenants on our business and related interest rate risk; the sufficiency of our cash and cash equivalents to meet our liquidity requirements; the volatility of our stock price; the amount and timing of repurchases, if any, under our stock repurchase program and our ability to enhance stockholder value through such program; our ability to maintain our good standing with the United States and international governments and capture new contracts with public sector entities; the occurrence of catastrophic events that may disrupt our business or that of our current and prospective clients; future acquisitions of, or investments in, complementary companies, products, subscriptions or technologies; and those discussed under the heading “Risk Factors” in Rimini Street’s Quarterly Report on Form 10-Q filed on July 30, 2026, and as updated from time to time by Rimini Street’s future Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and other filings by Rimini Street with the U.S. Securities and Exchange Commission. In addition, forward-looking statements provide Rimini Street’s expectations, plans or forecasts of future events and views as of the date of this communication. Rimini Street anticipates that subsequent events and developments will cause Rimini Street’s assessments to change. However, while Rimini Street may elect to update these forward-looking statements at some point in the future, Rimini Street specifically disclaims any obligation to do so, except as required by law. These forward-looking statements should not be relied upon as representing Rimini Street’s assessments as of any date subsequent to the date of this communication.

© 2026 Rimini Street, Inc. All rights reserved. “Rimini Street” is a registered trademark of Rimini Street, Inc. in the United States and other countries, and Rimini Street, the Rimini Street logo, and combinations thereof, and other marks marked by TM are trademarks of Rimini Street, Inc. All other trademarks remain the property of their respective owners, and unless otherwise specified, Rimini Street claims no affiliation, endorsement, or association with any such trademark holder or other companies referenced herein.

 

View source version on businesswire.com: https://www.businesswire.com/news/home/20260806244148/en/

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Contacts

Janet Ravin

VP, Corporate Marketing

Rimini Street, Inc.

+1 702 285-3532

pr@riministreet.com

 

NetApp Acquires JetStream Software to Advance Cyber Resilience and Data Protection for the AI Era

 SAN JOSE, Calif. - Thursday, 06. August 2026

Acquisition strengthens NetApp’s portfolio with recovery and mobility capabilities that help organizations reduce risk and accelerate transformation

 

(BUSINESS WIRE)--NetApp® (NASDAQ: NTAP), the Intelligent Data Infrastructure company, today announced it has acquired JetStream Software, a leader in VMware disaster recovery and migration.

Enterprise customers continue to rely on VMware for many of their most critical applications. As organizations evaluate cloud adoption, they often seek ways to transition workloads while minimizing cost, complexity, and operational disruption. For many, disaster recovery serves as a practical first step, with production workloads migrating over time as cloud strategies mature.

“Data has become the foundation for business growth, AI innovation, and operational continuity,” said George Kurian, Chief Executive Officer at NetApp. “As customers look to unlock greater value from their data while strengthening protection against disruption, bringing JetStream into NetApp expands our ability to help keep their data secure, available, and ready for what comes next. This acquisition further positions NetApp as a leader in enterprise resilience and data protection.”

By adding JetStream’s technology to NetApp, customers will be able to protect VMware environments running on virtually any storage platform and recover them on NetApp first-party storage offerings such as Azure NetApp Files.

“Customers want to move to the cloud on their schedule, not their infrastructure’s schedule,” said Pravjit Tiwana, Senior Vice President and General Manager, Cloud Storage and Services at NetApp. “JetStream helps customers start with disaster recovery and seamlessly evolve to production in the cloud. Together, we’re making our cloud offerings within hyperscalers the easiest destination for enterprise VMware workloads.”

JetStream complements NetApp’s existing SnapMirror technology, which remains the preferred replication solution for NetApp environments. Together, the combined portfolio enables NetApp to protect both existing NetApp deployments, and the much broader VMware installed base running on third-party storage.

With this acquisition, NetApp expands its ability to help enterprises protect applications, accelerate cloud migration, and modernize infrastructure while giving customers the flexibility to move at their own pace.

“Customers want solutions that help them evolve their environments without adding complexity,” said Tom Critser, Co-Founder and Chief Executive Officer at JetStream Software. “Joining NetApp allows us to bring our technology to more organizations worldwide and deliver even greater value by combining our expertise with NetApp’s industry-leading data services and cloud storage portfolio.”

"Safe Harbor" Statement Under U.S. Private Securities Litigation Reform Act of 1995

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements about the anticipated benefits of the acquisition of JetStream Software, including the ability to strengthen protection against disruption, keep customers’ data secure, available, and ready for what comes next, help enterprises protect applications, accelerate cloud migration, and modernize infrastructure, our business, economic and market outlook; our overall future prospects; demand for our AI solutions and other offerings; and our ability to deliver increasing results and value for our stakeholders. These and other important factors are described in reports and documents we file from time to time with the Securities and Exchange Commission, including the factors described under the sections titled "Risk Factors" in our most recently filed annual report on Form 10-K and quarterly report on Form 10-Q. All statements made in this release are made only as of the date set forth at the beginning of this release. We disclaim any obligation to update information contained in this press release whether as a result of new information, future events, or otherwise.

Statement of Product Direction

This press release discusses NetApp's vision for future innovation, including the anticipated alignment of JetStream Software's technology with NetApp’s portfolio. This information is shared solely for informational purposes and should not be relied upon in making purchasing decisions. NetApp makes no commitment and has no obligation to develop or deliver any products, services, integrations, or any related features, material, code or functionality described herein, including any capabilities resulting from the acquisition of JetStream Software. The development, release and timing of any features or functionality for NetApp products and services, including those offering JetStream Software's technology, remains at the sole discretion of NetApp. NetApp's strategy and possible future developments, product and platform directions, and functionality, including plans related to JetStream Software's technology, are all subject to change without notice. We disclaim any obligation to update information contained in this press release whether as a result of new information, future events, or otherwise.

About NetApp

For more than three decades, NetApp has helped the world’s leading organizations navigate change – from the rise of enterprise storage to the intelligent era defined by data and AI. Today, NetApp is the Intelligent Data Infrastructure company, helping customers turn data into a catalyst for innovation, resilience, and growth.

At the heart of that infrastructure is the NetApp data platform – the unified, enterprise-grade, intelligent foundation that connects, protects, and activates data across every cloud, workload, and environment. Built on the proven power of NetApp ONTAP, our leading data management software and OS, and enhanced by automation through the AI Data Engine and AFX, it delivers observability, resilience, and intelligence at scale.

Disaggregated by design, the NetApp data platform separates storage, services, and control so enterprises can modernize faster, scale efficiently, and innovate without lock-in. As the only enterprise storage platform natively embedded in the world’s largest clouds, it gives organizations the freedom to run any workload anywhere with consistent performance, governance, and protection.

With NetApp, data is always ready – ready to defend against threats, ready to power AI, and ready to drive the next breakthrough. That’s why the world’s most forward-thinking enterprises trust NetApp to turn intelligence into advantage. Learn more at www.netapp.com or follow us on X, LinkedIn, Facebook, and Instagram. NETAPP, the NETAPP logo, and the marks listed at www.netapp.com/TM are trademarks of NetApp, Inc. Other company and product names may be trademarks of their respective owners.

About JetStream Software

JetStream Software Inc., a leader in cyber resilience technology, provides cloud service providers (CSPs) and enterprise customers a simpler and more cost-efficient way to protect and recover workloads across cloud and multi-cloud infrastructures. JetStream Software complements hyperscale VMware-based cloud infrastructures, as well as protecting customers cloud native workloads. JetStream Software is headquartered in San Jose, California, with a subsidiary in Bangalore, India. Learn more at www.jetstreamsoft.com, and follow the company on LinkedIn.

 

View source version on businesswire.com: https://www.businesswire.com/news/home/20260806162687/en/

Permalink

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Contacts

Media Contact:

Kenya Hayes

NetApp

kenya.hayes@netapp.com

Investor Contact:

Kris Newton

NetApp

kris.newton@netapp.com